"Oneirine, and Methoneirine. Variations reported by Laszlo Jamf in the ACS Journal, year before last. Jamf was on loan again, this time as a chemist, to the Americans, whose National Research Council had begun a massive program to explore the morphine molecule and its possibilities—a Ten-Year Plan, coinciding, most oddly, with the classic study of large molecules being carried on by Carothers of du Pont, the Great Synthesist. Connection? Of course there's one. But we don't talk about it. NRC is synthesizing new molecules every day, most of them from pieces of the morphine molecule. Du Pont is stringing together groups such as amides into long chains. The two programs seem to be complementary, don't they? The American vice of modular repetition, combined with what is perhaps our basic search: to find something that can kill intense pain without causing addiction.

"Results have not been encouraging. We seem up against a dilemma built into Nature, much like the Heisenberg situation. There is nearly complete parallelism between analgesia and addiction. The more pain it takes away, the more we desire it. It appears we can't have one property without the other, any more than a particle physicist can specify position without suffering an uncertainty as to the particle's velocity—"